Cleft lip and palate (CLP) are among the most common congenital craniofacial anomalies worldwide, significantly affecting facial aesthetics, speech, hearing, feeding, dental development, psychosocial well-being, and quality of life. Advances in surgical techniques, orthodontic treatment, prosthodontic rehabilitation, speech therapy, regenerative medicine, and digital technologies have transformed the management of individuals with cleft deformities. Modern rehabilitation emphasizes a multidisciplinary approach involving surgeons, orthodontists, prosthodontists, speech-language pathologists, psychologists, audiologists, and genetic counselors. This review examines recent advances in cleft lip and palate rehabilitation, including innovations in presurgical orthopedics, digital treatment planning, three-dimensional imaging, computer-aided design/computer-aided manufacturing (CAD/CAM), tissue engineering, and patient-centered care. The study highlights improved clinical outcomes achieved through comprehensive rehabilitation protocols and discusses future directions in personalized craniofacial care.