Maxillofacial prosthetics is a specialized branch of prosthodontics focused on restoring congenital or acquired defects of the head and neck region through prosthetic rehabilitation. Patients suffering from defects caused by trauma, oncologic surgery, congenital anomalies, or infectious diseases often experience significant functional, aesthetic, and psychological challenges. Recent technological advancements have transformed maxillofacial prosthetic rehabilitation through the integration of digital workflows, three-dimensional (3D) imaging, computer-aided design/computer-aided manufacturing (CAD/CAM), additive manufacturing, biocompatible materials, osseointegrated implants, and artificial intelligence. These innovations have significantly improved prosthesis accuracy, retention, comfort, aesthetics, and patient satisfaction. This review explores contemporary developments in maxillofacial prosthetics, highlighting emerging technologies, clinical applications, challenges, and future directions in the field.