Bone grafting has become an essential component of modern oral and maxillofacial reconstruction, enabling restoration of alveolar bone defects, enhancement of implant placement sites, management of traumatic injuries, and reconstruction following tumor resection. Various bone grafting materials are currently available, including autografts, allografts, xenografts, and alloplastic substitutes, each possessing unique biological and clinical characteristics. The selection of an appropriate graft material depends on defect size, anatomical location, patient factors, regenerative potential, and treatment objectives. This review comprehensively examines contemporary bone grafting materials used in oral reconstruction, emphasizing biological properties, mechanisms of action, clinical indications, advantages, limitations, and treatment outcomes. Emerging technologies such as tissue engineering, stem cell therapy, growth factors, and three-dimensional (3D) bioprinting are also discussed. Current evidence suggests that while autogenous bone remains the gold standard, biomaterial innovations are increasingly improving clinical outcomes and reducing donor-site morbidity. Future developments in regenerative medicine are expected to transform oral reconstruction and enhance patient care.