Digital Smile Design (DSD) has emerged as a revolutionary approach in modern prosthodontics, integrating digital technologies, facial analysis, esthetic principles, and interdisciplinary treatment planning to create predictable and patient-centered smile rehabilitations. Traditional smile design methods often relied on subjective clinical judgment and two-dimensional analyses, which could limit treatment predictability and patient communication. Digital Smile Design utilizes digital photography, videography, facial scanning, computer-aided design software, and virtual simulations to evaluate dentofacial relationships and create customized treatment plans. This review examines the principles, workflow, clinical applications, benefits, limitations, and future perspectives of Digital Smile Design in prosthodontics. Findings indicate that DSD enhances diagnostic accuracy, improves patient communication, facilitates interdisciplinary collaboration, and increases treatment predictability. Despite challenges such as software costs, learning curves, and standardization issues, DSD has become a valuable tool in esthetic and restorative dentistry. The study concludes that Digital Smile Design is transforming prosthodontic practice by enabling personalized, minimally invasive, and highly aesthetic treatment outcomes.