Occlusion is a fundamental determinant of success in prosthetic dentistry. Proper occlusal design influences masticatory efficiency, prosthesis longevity, patient comfort, temporomandibular joint health, and overall treatment outcomes. Inadequate occlusal planning may result in biological complications, mechanical failures, restoration fracture, periodontal breakdown, and temporomandibular disorders. Contemporary prosthetic rehabilitation requires a comprehensive understanding of static and dynamic occlusion, occlusal schemes, articulator use, digital occlusal analysis, implant occlusion, and full-mouth rehabilitation concepts. This review examines current occlusal principles in fixed, removable, and implant-supported prosthodontics, highlighting advances in digital dentistry and evidence-based approaches to occlusal management. The article emphasizes the importance of individualized occlusal planning to optimize function, esthetics, and long-term prosthetic success.