Full-mouth rehabilitation (FMR) is a comprehensive restorative treatment approach aimed at restoring oral function, esthetics, phonetics, occlusal harmony, and overall oral health in patients with extensive dental deterioration. The success of full-mouth rehabilitation has traditionally been measured through clinical parameters; however, patient satisfaction has emerged as a critical outcome indicator in modern dentistry. This review examines patient satisfaction associated with full-mouth rehabilitation by analyzing functional outcomes, esthetic improvements, psychological impacts, oral health-related quality of life (OHRQoL), treatment expectations, and long-term clinical success. Evidence indicates that successful rehabilitation significantly improves mastication, speech, facial aesthetics, self-confidence, and social interactions. Factors influencing satisfaction include treatment planning, clinician-patient communication, prosthetic quality, treatment duration, cost considerations, and maintenance protocols. Emerging digital technologies, including computer-aided design/computer-aided manufacturing (CAD/CAM), digital smile design, artificial intelligence, and implant-supported rehabilitation, are further enhancing treatment predictability and patient-centered outcomes. This review highlights the importance of integrating subjective patient-reported outcomes with objective clinical measures to achieve optimal rehabilitation success.