Platelet-Rich Fibrin in Oral Surgical Procedures: Biological Basis, Clinical Applications, and Future Perspectives

doi:N/A

Global Journal of Dental Specialty

2023, Volume 1, Issue 3 : 1-6

Research Article

Platelet-Rich Fibrin in Oral Surgical Procedures: Biological Basis, Clinical Applications, and Future Perspectives

Andrew J. Collins

Neha Verma

Omar H. Al-Farouq

Department of Oral and Maxillofacial Surgery, Global Dental Research Institute, New York, USA

Department of Periodontology and Implant Dentistry, International College of Dental Sciences, New Delhi, India

Department of Oral Biology and Regenerative Medicine, European School of Dentistry, Madrid, Spain

Abstract

Platelet-Rich Fibrin (PRF) is a second-generation autologous platelet concentrate that has gained significant attention in oral and maxillofacial surgery due to its regenerative potential and ease of preparation. Unlike Platelet-Rich Plasma (PRP), PRF does not require anticoagulants or biochemical additives and provides a natural fibrin matrix rich in platelets, leukocytes, cytokines, and growth factors. These biological components promote wound healing, angiogenesis, tissue regeneration, and bone formation. PRF has been successfully utilized in various oral surgical procedures including tooth extractions, implant placement, sinus augmentation, ridge preservation, periodontal regeneration, and management of medication-related osteonecrosis of the jaw. This review explores the biological mechanisms, preparation protocols, clinical applications, advantages, limitations, and future developments of PRF in oral surgery. Evidence suggests that PRF significantly improves soft tissue healing, enhances bone regeneration, reduces postoperative complications, and contributes to improved patient outcomes. Continued advancements in PRF technology and regenerative medicine are expected to further expand its role in modern oral surgical practice.

Keywords

Platelet-Rich Fibrin

PRF

Oral Surgery

Regenerative Dentistry

Bone Regeneration

Growth Factors

Implant Dentistry

Wound Healing

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