Precision medicine has emerged as a transformative paradigm in healthcare, shifting clinical practice from generalized treatment approaches to individualized patient care based on genetic, molecular, environmental, and lifestyle factors. In oral pathology, precision medicine offers significant opportunities for improving disease diagnosis, prognosis, prevention, and treatment. The integration of genomics, transcriptomics, proteomics, metabolomics, artificial intelligence, and molecular diagnostics has enhanced understanding of the biological mechanisms underlying oral diseases. This review explores current precision medicine approaches in oral pathology, including applications in oral potentially malignant disorders, oral squamous cell carcinoma, salivary gland diseases, autoimmune conditions, and infectious diseases. The study highlights technological advancements, clinical applications, benefits, challenges, and future prospects of personalized oral healthcare. The findings suggest that precision medicine can significantly improve patient outcomes through targeted therapies, early disease detection, and individualized treatment planning.