Successful endodontic treatment depends on effective cleaning, shaping, and disinfection of the root canal system. Mechanical instrumentation alone cannot adequately eliminate microorganisms, tissue remnants, smear layer, and biofilms from the complex anatomy of root canals. Root canal irrigation plays a critical role in enhancing debridement and disinfection. Over the last two decades, substantial advancements have been made in irrigation solutions, activation systems, and delivery technologies aimed at improving irrigant penetration and antimicrobial efficacy. Contemporary irrigation technologies include sonic activation, ultrasonic activation, laser-assisted irrigation, negative-pressure systems, multisonic technologies, and nanoparticle-enhanced irrigants. This review examines the evolution, principles, clinical applications, advantages, limitations, and future directions of root canal irrigation technologies. The findings suggest that advanced irrigation systems significantly improve canal cleanliness and treatment outcomes compared to conventional syringe irrigation. Emerging technologies involving artificial intelligence, nanotechnology, and smart irrigation systems may further transform endodontic practice.