Fixed dental restorations play a critical role in restoring function, aesthetics, and oral health. For decades, metal-ceramic restorations have been regarded as the gold standard due to their durability and predictable clinical performance. However, advancements in dental materials and digital manufacturing technologies have led to the widespread adoption of zirconia-based restorations. Zirconia offers superior aesthetics, excellent biocompatibility, high flexural strength, and compatibility with digital workflows. Despite these advantages, concerns remain regarding long-term wear characteristics, bonding challenges, and veneer chipping. This review provides a comprehensive comparison between zirconia and metal-ceramic restorations regarding material properties, fabrication methods, clinical performance, aesthetics, biological response, survival rates, complications, and future developments. Current evidence suggests that both materials demonstrate high clinical success; however, zirconia has emerged as a preferred option in contemporary prosthodontics due to its superior aesthetic outcomes and compatibility with modern digital dentistry.